Metabolic preconditioning protects BSEP/ABCB11−/− mice against cholestatic liver injury
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چکیده
منابع مشابه
Chicken bile powder protects against α-naphthylisothiocyanate-induced cholestatic liver injury in mice
This study explored the effects of chicken bile powder (CBP), a 2000-year-old Chinese medicine, on α-naphthyl isothiocyanate (ANIT)-induced intrahepatic cholestasis in mice. CBP treatment for 14 days significantly ameliorated ANIT-induced changes in serum alanine aminotransferase, aspartate aminotransferase, bile acids, bilirubin, γ-glutamyl transpeptidase, alkaline phosphatase, and liver tissu...
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PURPOSE To determine the effect of grape-seed extract against ischemia/reperfusion injury in cholestatic liver. METHODS Eighteen Wistar albino rats were divided into three groups. In control and study groups, cholestasis was provided by bile duct ligation. Seven days later, the rats were subjected to 30 min hepatic ischemia, followed by 60 min of reperfusion. Oral administration of 50 mg/kg/d...
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Acetaminophen toxicity has become a leading cause of both accidental and intentional poisoning, and is now the most common cause of acute liver failure in the United States. Acetaminophen poisoning is thus a significant burden on the health care system and a cause of considerable morbidity and mortality. Tetrathiomolybdate is a fast acting anticopper drug developed for Wilson’s disease. However...
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Tetrathiomolybdate (TM), a potent copper-chelating drug, was initially developed for the treatment of Wilson's disease. Our working hypothesis is that the fibrotic pathway is copper-dependent. Because biliary excretion is the major pathway for copper elimination, a bile duct ligation (BDL) mouse model was used to test the potential protective effects of TM. TM was given in a daily dose of 0.9 m...
متن کاملRemote Ischemic Preconditioning Protects against Liver Ischemia-Reperfusion Injury via Heme Oxygenase-1-Induced Autophagy
BACKGROUND Growing evidence has linked autophagy to a protective role of preconditioning in liver ischemia/reperfusion (IR). Heme oxygenase-1 (HO-1) is essential in limiting inflammation and preventing the apoptotic response to IR. We previously demonstrated that HO-1 is up-regulated in liver graft after remote ischemic preconditioning (RIPC). The aim of this study was to confirm that RIPC prot...
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ژورنال
عنوان ژورنال: Journal of Hepatology
سال: 2017
ISSN: 0168-8278
DOI: 10.1016/j.jhep.2016.08.017